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Your Position: Home > Fc gamma RIIA / CD32a

Fc gamma RIIA / CD32a

Brief Information

Name:Low affinity immunoglobulin gamma Fc region receptor II-a
Target Synonym:Low affinity immunoglobulin gamma Fc region receptor II-a,FCGR2A1,Fc-gamma RII-a,CD32,FCGR2A,Fc Fragment Of IgG Receptor IIa,Fc Fragment Of IgG, Low Affinity IIa, Receptor (CD32),Immunoglobulin G Fc Receptor II,IGFR2,FCG2,Fc Fragment Of IgG, Low Affinity IIa, Receptor For (CD32),Fc Gamma Receptor IIa,CD32 Antigen,CD32A,FCGR2,IgG Fc receptor II-a,CDw32,Fc-gamma-RIIa,FcRII-a,FcGR,Fc Gamma Receptor RIIa3
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:2
Lastest Research Phase:Phase 1 Clinical

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Cat. No. Species Product Description Structure Purity Feature
FRT-05 Human Human Fc gamma RIIA / CD32a (R167) binding Kit (TR-FRET)
FRT-04 Human Human Fc gamma RIIA / CD32a (H167) binding Kit (TR-FRET)
CDA-H5284 Human Human Fc gamma RIIA / CD32a (H167) Protein, Strep Tag (MALS & SPR verified)
CDA-H5284-structure
CDA-H5284-sds
CDA-H5283 Human Human Fc gamma RIIA / CD32a (R167) Protein, Strep Tag (MALS & SPR verified)
CDA-H5283-structure
CDA-H5283-sds
SCCHO-ATP061M Human CHO/Human CD32a Stable Cell Line (Medium Expression)
SCCHO-ATP061H Human CHO/Human CD32a Stable Cell Line (High Expression)
SCCHO-ATP061L Human CHO/Human CD32a Stable Cell Line (Low Expression)
CDA-H82E5 Human Biotinylated Human Fc gamma RIIA / CD32a (R167) Protein, His,Avitag™ (MALS & SPR verified)
CDA-H82E5-structure
CDA-H82E5-sds
CDA-R52H5 Rat Rat Fc gamma RIIA / CD32a Protein, His Tag (MALS & SPR verified)
CDA-R52H5-structure
CDA-R52H5-sds
CDA-R52H4 Rhesus macaque Rhesus macaque Fc gamma RIIA / CD32a Protein, His Tag (SPR & BLI & MALS verified)
CDA-R52H4-structure
CDA-R52H4-sds
CDA-C52H7 Cynomolgus Cynomolgus Fc gamma RIIA / CD32a Protein, His Tag (SPR & BLI & MALS verified)
CDA-C52H7-structure
CDA-C52H7-sds
CDA-C82E5 Cynomolgus Biotinylated Cynomolgus Fc gamma RIIA / CD32a Protein, His,Avitag™ (SPR & BLI & MALS verified)
CDA-C82E5-structure
CDA-C82E5-sds
CDA-H5221 Human Human Fc gamma RIIA / CD32a (R167) Protein, His Tag (MALS & BLI verified)
CDA-H5221-structure
CDA-H5221-sds
CDA-H82E6 Human Biotinylated Human Fc gamma RIIA / CD32a (H167) Protein, Avitag™,His Tag (SPR & BLI & MALS verified)
CDA-H82E6-structure
CDA-H82E6-sds
CD1-H5223 Human Human Fc gamma RIIA / CD32a (H167) Protein, His Tag (SPR & BLI & MALS verified)
CD1-H5223-structure
CD1-H5223-sds
ACRO Quality

Part of Bioactivity data

SCCHO-ATP061M-Cell-based assay
Fc gamma RIIA / CD32a FACS

Expression analysis of human CD32a on CHO/Human CD32a Stable Cell Line by FACS.
Cell surface staining using PE-labeled anti-human CD32a antibody was performed on CHO/Human CD32a Stable Cell Line with different expression levels: CHO/Human CD32a Stable Cell Line (Low Expression); CHO/Human CD32a Stable Cell Line (Medium Expression); CHO/Human CD32a Stable Cell Line (High Expression).

Protocol
SCCHO-ATP061H-Cell-based assay
Fc gamma RIIA / CD32a FACS

Expression analysis of human CD32a on CHO/Human CD32a Stable Cell Line (High Expression) by FACS.
Cell surface staining using PE-labeled anti-human CD32a antibody was performed on CHO/Human CD32a Stable Cell Line with different expression levels: CHO/Human CD32a Stable Cell Line (Low Expression); CHO/Human CD32a Stable Cell Line (Medium Expression); CHO/Human CD32a Stable Cell Line (High Expression).

Protocol
CDA-H5284-SPR
Fc gamma RIIA / CD32a SPR

Human CD32a (H167) Protein, Strep Tag (Cat. No. CDA-H5284) immobilized on CM5 Chip can bind Rituximab with an affinity constant of 1.47 μM as determined in a SPR assay (Biacore 8K) (QC tested).

Protocol
CDA-H5284-SPR
Fc gamma RIIA / CD32a SPR

Rituximab immobilized on CM5 Chip can bind Human CD32a (H167) Protein, Strep Tag (Cat. No. CDA-H5284) with an affinity constant of 1.9 μM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol

Customer Reviews

Synonym Name

CD32a,FCGR2A,CD32,FCG2 ,FCGR2A1,IGFR2

Background

Receptors for the Fc region of IgG (Fc γ R) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Three classes of human Fc γ Rs: RI (CD64), RII (CD32), and RIII (CD16), which generate multiple isoforms, are recognized. There are three genes for human Fcγ RII /CD32 (A, B, and C) and one for mouse Fcγ RII B (CD32B). CD32 is a low affinity receptor for IgG. The activating isoform, CD32A, is expressed on monocytes, neutrophils, platelets and dendritic cells. CD32A is expressed on many immune cell types (macrophage, neutrophil, eosinophils, platelets, dendritic cells and Langerhan cells), where inhibitory ITIM­bearing receptors may also be coexpressed and co­engaged by specific ligands. CD32A delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation and cytokine production. The responses can be modulated by signals from the coexpressed inhibitory receptors such as CD32B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.

Clinical and Translational Updates

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